Numerous therapies designed to intervene in the proinflammatory cascade alone have failed louisville-slug-fest-2013-uci-cyclocross-world-championships to alter the outcome of sepsis in recent years [18 ]. monocyte) dysfunction [16 ]. Although definitive evidence is lacking, predilution fluid louisville-slug-fest-2013-uci-cyclocross-world-championships replacement also is believed to enhance filter patency during CRRT and to reduce need for anticoagulation [15 ]. Hence, ultrafiltration must be relatively increased to maintain the same efficiency of solute removal as is observed in postdilution mode [12 -14 ].
However, at a given ultrafiltration rate, predilution results in reduced solute clearance as compared with postdilution because of dilution of solutes at blood entry into the filter. This, along with increased replacement fluid rate and a more porous louisville-slug-fest-2013-uci-cyclocross-world-championships membrane, can enhance solute clearance. Conversely, predilution CRRT is not limited by filtration fraction and therefore allows for higher ultrafiltration rates. The efficiency of postdilution CRRT is limited by the maximum acceptable value of filtration fraction and by the maximal blood flow that can be louisville-slug-fest-2013-uci-cyclocross-world-championships delivered by the access.